Study title: Comparative immune response to Covid-19 vaccine(s) against receptor binding domain (RBD) of the spike protein of SARS-CoV-2 among participants with and without prior COVID-19 infection.
Bangladesh has begun a countrywide immunization program for COVID-19 from February 7, 2021. Natural infection in populations by SARS-CoV-2 can result in seropositivity against the virus. Investigations in Bangladesh have demonstrated that both symptomatic and asymptomatic disease in COVID-19 patients can stimulate production of IgG and IgM antibodies. However, it is critical to evaluate the pattern and length of the immune response following vaccination, as well as determine the peak response.
The purpose of this 15-month-long study is analyzing the antibody titers to compare the pattern of immune response among asymptomatic, mild, moderate and severe COVID-19-infected and non-COVID-19-infected population of Bangladesh following vaccination against COVID-19.
Study title: Fighting Covid-19 in Bangladeshi and Rohingya populations with endemic bacterial diarrhoea and antimicrobial resistance.
This study is being conducted in parallel by ideSHi, IEDCR, icddr,b and University of Nottingham. The aim is to gather data from Bangladeshi and Rohingya COVID-19 patients on the severity of viral infection, pre-existing enteric bacterial infections, treatment, course of illness (including evolution of gut microbiome) and final outcome. Clinical data, whole-metagenome sequencing, treatment and course will be collected and aggregated into a data vault for this and future studies. Machine learning will be used to identify correlations between COVID-19, enteric bacterial infections, treatment and evolution of gut microbiome and antimicrobial resistance (AMR).
Study title: SARS-CoV-2 detection and serological response in ‘Forcibly Displaced Myanmar Nationals’ in Cox’s Bazar.
The objective of this study is to conduct investigations to understand transmission and epidemiological patterns of SARS-CoV-2 circulation in the selected FDMNs, evaluate the serological response to SARS-CoV-2 from identified COVID-19 cases and their households. ideSHi is collaborating with Fondation Mérieux for this project.