Dr. Kaiissar Mannoor is a cellular and molecular biologist with a long-standing interest in protective immune responses to infectious diseases with special emphasis on malaria and diarrheal pathogens. He has made an outstanding contribution to deciphering the role of autoreactive B cells and their associated antibody and cytokine products in the regulation of immune responses during infections and autoimmune diseases. Dr. Mannoor has also made significant contributions in transcriptome biology, especially as a pioneer in defining the role of non-coding RNA (small nucleolar RNA 42) in the development of non-small cell lung cancer stem cells. Dr. Mannoor has served as Assistant Professor on the faculty of the University of Rykyus School of Medicine, Japan, and as an adjunct faculty member (Assistant Research Scientist) at the Biodesign Institute of Arizona State University, USA. Dr Mannoor also worked as a Postdoctoral Fellow in the University of Maryland School of Medicine at Baltimore, and conducted research on autoimmunity and lung cancer biology. He has recently repatriated from the USA and currently working as Head of ideSHi. He supervises day-to-day operations and all laboratory activities that deal with projects on infectious diseases, such as typhoid fever, acute respiratory infections, and food-borne illness surveillance, as well as genetic disorders.

Hossain M, Noor FA, Bhuyan GS, Qadri SS, Mannoor K1. Role of XmnI Polymorphism in HbF Induction in HbE/β and β-Thalassaemia Patients. Bangladesh Med Res Counc Bull. 2019 ; 45:133-142 DOI: https://doi.org/10.3329/bmrcb.v45i3.44642

Noor FA, Sultana N, Bhuyan GS, Islam MT, Hossain M, Sarker SK et al. Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population. Orphanet Journal of Rare Diseases. 2020; doi.org/10.1186/s13023-020-1294-z

Sarker SK, Islam MT, Hasib SH, Sultana N, Hossain SR, Biswas A et al. A novel missense mutation of Isovaleryl-CoA dehydrogenase gene associated with chronic intermittent Isovaleric acidemia in a Bangladeshi patient. Meta Gene. 2019; doi.org/10.1016/j.mgene.2019.100557

Begum MN, Islam MT, Hossain SR, Bhuyan GS, Halim MA, Shahriar I et al. Mutation Spectrum in TPO Gene of Bangladeshi Patients with Thyroid Dyshormonogenesis and Analysis of the Effects of Different Mutations on the Structural Features and Functions of TPO Protein through In Silico Approach. BioMed Research International. 2019; 10.1155/2019/9218903

Sarker SK, Islam MT, Biswas A, Bhuyan GS, Sultana R, Sultana N et al. Age-Specific Cut-off Values of Amino Acids and Acylcarnitines for Diagnosis of Inborn Errors of Metabolism Using Liquid Chromatography Tandem Mass Spectrometry. BioMed Research International. 2019; 10.1155/2019/3460902

Islam MT, Sarker SK, Shithi ST, Bhuyan GS, Rahat A, Islam NN et al. High resolution melting curve analysis enables rapid and reliable detection of G6PD variants in heterozygous females. BMC Genetics. 2018;19(1).

Sarker SK, Islam MT, Bhuyan GS, Sultana N, Begum MN, Al Mahmud-Un-Nabi M et al. Impaired acylcarnitine profile in transfusion-dependent beta-thalassemia major patients in Bangladesh. J. Adv. Res. 2018;12:55-66.

Islam MT, Sarker SK, Sultana N, Begum MN, Bhuyan GS, et al. (2018) High resolution melting curve analysis targeting the HBB gene mutational hot-spot offers a reliable screening approach for all common as well as most of the rare beta-globin gene mutations in Bangladesh. BMC Genetics 19:1 doi:10.1186/s12863-017-0594-3

Bhuyan GS, Hossain MA, Sarker SK, Rahat A, Islam MT, et al. (2017) Bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in Dhaka city. PLOS ONE 12(3): e0174488. doi: 10.1371/journal.pone.0174488

Al‐Mamun MM, Sarker SK, Qadri SK, Shirin T, Mohammad QD, LaRocque R, Karlsson EK, Saha N, Asaduzzaman M, Qadri F, Mannoor MK. Examination of Huntington’s disease with atypical clinical features in a Bangladeshi family tree. Clinical Case Reports. 2016 Dec 1;4(12):1191-4.

Sarker SK, Islam MT, Eckhoff G, Hossain MA, Qadri SK, Muraduzzaman AK, Bhuyan GS, Shahidullah M, Mannan MA, Tahura S, Hussain M. Molecular Analysis of Glucose-6-Phosphate Dehydrogenase Gene Mutations in Bangladeshi Individuals. PloS one. 2016 Nov 23;11(11):e0166977.

Yu L, Shen J, Mannoor K, Guarnera M, Jiang F. Identification of ENO1 as a potential sputum biomarker for early-stage lung cancer by shotgun proteomics. Clinical lung cancer. 2014 Sep 30;15(5):372-8.

Mannoor K, Shen J, Liao J, Liu Z, Jiang F. Small nucleolar RNA signatures of lung tumor-initiating cells. Molecular cancer. 2014 May 6;13(1):104.

Ma J, Mannoor K, Gao L, Tan A, Guarnera MA, Zhan M, Shetty A, Stass SA, Xing L, Jiang F. Characterization of microRNA transcriptome in lung cancer by next-generation deep sequencing. Molecular oncology. 2014 Oct 31;8(7):1208-19.

Wang J, Tian X, Han R, Zhang X, Wang X, Shen H, Xue L, Liu Y, Yan X, Shen J, Mannoor K. Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene. 2014 Feb 27;33(9):1181-9.

Mannoor K, Li C, Inafuku M, Taniguchi T, Abo T, Sato Y, Watanabe H. Induction of ssDNA-binding autoantibody secreting B cell immunity during murine malaria infection is a critical part of the protective immune responses. Immunobiology. 2013 Jan 31;218(1):10-20.

Mannoor K, Xu Y, Chen C. Natural autoantibodies and associated B cells in immunity and autoimmunity. Autoimmunity. 2013 Mar 1;46(2):138-47.

Mannoor K, Matejuk A, Xu Y, Beardall M, Chen C. Expression of natural autoantibodies in MRL-lpr mice protects from lupus nephritis and improves survival. The Journal of Immunology. 2012 Apr 15;188(8):3628-38.

Li C, Mannoor K, Inafuku M, Taniguchi T, Inamine Y, Miyazaki T, Watanabe H. Protective function of an unconventional γδ T cell subset against malaria infection in apoptosis inhibitor deficient mice. Cellular immunology. 2012 Oct 31;279(2):151-9.

Mannoor K, Liao J, Jiang F. Small nucleolar RNAs in cancer. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2012 Aug 31;1826(1):121-8.

Toma H, Hatabu T, Vanisaveth V, Mannoor MK, Watanabe H, Li C, Kobayashi J, Phompida S, Kano S, Sato Y. Efficacy of mefloquine treatment and genetic profiles in uncomplicated Plasmodium falciparum malaria in southern Lao PDR. Southeast Asian Journal of Tropical Medicine and Public Health. 2011 Jul 1;42(4):759.

Yu L, Slovak ML, Mannoor K, Chen C, Hunger SP, Carroll AJ, Schultz RA, Shaffer LG, Ballif BC, Ning Y. Microarray detection of multiple recurring submicroscopic chromosomal aberrations in pediatric T-cell acute lymphoblastic leukemia. Leukemia. 2011 Jun 1;25(6):1042-7.

Li C, Mannoor MK, Toma N, Taniguchi T, Inafuku M, Yamaguchi KK, Sato Y, Watanabe H. The efficacy of Royal Jelly in the restoration of alcoholic liver injury in mouse model. Biomedical Research. 2011;22(1).

Matejuk A, Beardall M, Xu Y, Tian Q, Phillips D, Alabyev B, Mannoor K, Chen C. Exclusion of natural autoantibody-producing B cells from IgG memory B cell compartment during T cell-dependent immune responses. The Journal of Immunology. 2009 Jun 15;182(12):7634-43.

Mannoor MK, Shimabukuro I, Tsukamotoa M, Watanabe H, Yamaguchi K, Sato Y. Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB× NZW F1 mice. Lupus. 2009 Jan;18(1):44-52.

Shamsuzzaman S, Ahmed T, Mannoor K, Begum YA, Bardhan PK, Sack RB, Sack DA, Svennerholm AM, Holmgren J, Qadri F. Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responses. Vaccine. 2009 Feb 25;27(9):1386-92.

Mannoor MK, Tsukamoto M, Watanabe H, Yamaguchi K, Sato Y. The efficacy of royal jelly in the restoration of stress-induced disturbance of lymphocytes and granulocytes. Biomedical Research-India. 2008 May 1;19(2):69-77.

Ariyasinghe A, Morshed SR, Mannoor MK, Bakir HY, Kawamura H, Miyaji C, Nagura T, Kawamura T, Watanabe H, Sekikawa H, Abo T. Protection against malaria due to innate immunity enhanced by low-protein diet. Journal of Parasitology. 2006 Jun;92(3):531-8.

Halder RC, Abe T, Mannoor MK, Morshed SR, Ariyasinghe A, Watanabe H, Kawamura H, Sekikawa H, Hamada H, Nishiyama Y, Ishikawa H. Onset of hepatic erythropoiesis after malarial infection in mice. Parasitology international. 2003 Dec 31;52(4):259-68.

Mannoor MK, Halder RC, Morshed SR, Ariyasinghe A, Bakir HY, Kawamura H, Watanabe H, Sekikawa H, Abo T. Essential role of extrathymic T cells in protection against malaria. The Journal of Immunology. 2002 Jul 1;169(1):301-6.

Morshed SR, Mannoor K, Halder RC, Kawamura H, Bannai M, Sekikawa H, Watanabe H, Abo T. Tissue‐specific expansion of NKT and CD5+ B cells at the onset of autoimmune disease in (NZB× NZW) F1 mice. European journal of immunology. 2002 Sep 1;32(9):2551-61.

HALDER RC, WATANABE H, KAMEYAME H, MANNOOR MK, MORSHED SR, ARIYASHINGHE A, ABO T. Activation of extrathymic T cells and granulocytes in the liver and intestine by intraperitoneal administration of cholera toxin. Biomedical Research. 2001;22(3):137-46.

Weerasinghe A, Sekikawa H, Watanabe H, Mannoor MK, Morshed SR, Halder RC, Kawamura T, Kosaka T, Miyaji C, Kawamura H, Seki S. Association of intermediate T cell receptor cells, mainly their NK1. 1− subset, with protection from malaria. Cellular immunology. 2001 Jan 10;207(1):28-35.

Halder RC, Kawamura T, Bannai M, Watanabe H, Kawamura H, Mannoor MK, Morshed SR, Abo T. Intensive generation of NK1. 1–extrathymic T cells in the liver by injection of bone marrow cells isolated from mice with a mutation of polymorphic major histocompatibility complex antigens. Immunology. 2001 Apr 1;102(4):450-9.

Mannoor MK, Weerasinghe A, Halder RC, Reza S, Morshed M, Ariyasinghe A, Watanabe H, Sekikawa H, Abo T. Resistance to malarial infection is achieved by the cooperation of NK1. 1+ and NK1. 1− subsets of intermediate TCR cells which are constituents of innate immunity. Cellular immunology. 2001 Aug 1;211(2):96-104.

KAWAMURA T, HALDER RC, ABO T. Negative Regulation of Activated Granulocytes in Number and Function by Lactoferrin. Biomedical Research. 1999;20(4):205-11.

Qadri F, Mäkelä PH, Holmgren J, Albert MJ, Mannoor K, Kantele A, Saha D, Salam MA, Kantele JM. Enteric infections in an endemic area induce a circulating antibody-secreting cell response with homing potentials to both mucosal and systemic tissues. Journal of Infectious Diseases. 1998 Jun 1;177(6):1594-9.

Qadri F, Wennerås C, Albert MJ, Hossain J, Mannoor K, Begum YA, Mohi G, Salam MA, Sack RB, Svennerholm AM. Comparison of immune responses in patients infected with Vibrio cholerae O139 and O1. Infection and immunity. 1997 Sep 1;65(9):3571-6.

Mannoor MK, Vanisaveth V, Keokhamphavanh B, Toma H. Pyrimethamine-sulfadoxine treatment of uncomplicated Plasmodium Falciparum malaria in Lao PDR. Southeast Asian journal of tropical medicine and public health. 2005 Sep 1;36(5):1092.

HATABU T, VANISAVETH V, TAGUCHI N, KOBAYASHI J, MANNOOR MK, WATANABE H, TOMA H, PHOMPIDA S, KANO S. A pilot field survey on the in vitro drug susceptibility of Plasmodium falciparum in Lao PDR. Tropical Medicine and Health. 2005;33(2):103-4.

Watanabe H, Weerasinghe A, Miyaji C, Sekikawa H, Toyabe S, Mannor MK, Morshed SR, Halder RC, Kobayashi J, Toma H, Sato Y. Expansion of unconventional T cells with natural killer markers in malaria patients. Parasitology international. 2003 Mar 31;52(1):61-70.

Wang J, Tian X, Han R, Zhang X, Wang X, Shen H, Xue L, Liu Y, Yan X, Shen J, Mannoor K. Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer. Oncogene. 2014 Feb 27;33(9):1181-9.